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3fav

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==Structure of the CFP10-ESAT6 complex from Mycobacterium tuberculosis==
==Structure of the CFP10-ESAT6 complex from Mycobacterium tuberculosis==
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<StructureSection load='3fav' size='340' side='right' caption='[[3fav]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='3fav' size='340' side='right'caption='[[3fav]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fav]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FAV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fav]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FAV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wa8|1wa8]], [[2vrz|2vrz]], [[2vs0|2vs0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">esxB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), esxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fav OCA], [https://pdbe.org/3fav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fav RCSB], [https://www.ebi.ac.uk/pdbsum/3fav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fav ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fav OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fav RCSB], [http://www.ebi.ac.uk/pdbsum/3fav PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ESXA_MYCTU ESXA_MYCTU]] Not known. Elicits high level of IFN-gamma from memory effector cells during the first phase of a protective immune response.
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[https://www.uniprot.org/uniprot/ESXB_MYCTU ESXB_MYCTU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/3fav_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/3fav_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fav ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3fav" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Holton, S J]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Poulsen, C]]
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[[Category: Holton SJ]]
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[[Category: Song, Y H]]
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[[Category: Poulsen C]]
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[[Category: Wilmanns, M]]
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[[Category: Song YH]]
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[[Category: Adaptor protein]]
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[[Category: Wilmanns M]]
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[[Category: Coiled-coil]]
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[[Category: Complex]]
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[[Category: Four-helical-bundle]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Operon structure]]
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[[Category: Proposed virulent factor]]
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[[Category: Secreted]]
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[[Category: Secretion system]]
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[[Category: Viral protein]]
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[[Category: Wxg-motif]]
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Current revision

Structure of the CFP10-ESAT6 complex from Mycobacterium tuberculosis

PDB ID 3fav

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Proteopedia Page Contributors and Editors (what is this?)

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