This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3fzk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:34, 1 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors==
==Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors==
-
<StructureSection load='3fzk' size='340' side='right' caption='[[3fzk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+
<StructureSection load='3fzk' size='340' side='right'caption='[[3fzk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3fzk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FZK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FZK FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3fzk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FZK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FZK FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3BK:(2R,3R,4S,5R)-2-[6-AMINO-8-[(3,4-DICHLOROPHENYL)METHYLAMINO]PURIN-9-YL]-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL'>3BK</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fzf|3fzf]], [[3fzh|3fzh]], [[3fzl|3fzl]], [[3fzm|3fzm]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BK:(2R,3R,4S,5R)-2-[6-AMINO-8-[(3,4-DICHLOROPHENYL)METHYLAMINO]PURIN-9-YL]-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL'>3BK</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSPA8, HSC70, HSP73, HSPA10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), BAG1, HAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fzk OCA], [https://pdbe.org/3fzk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fzk RCSB], [https://www.ebi.ac.uk/pdbsum/3fzk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fzk ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fzk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fzk OCA], [http://pdbe.org/3fzk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fzk RCSB], [http://www.ebi.ac.uk/pdbsum/3fzk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fzk ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> [[http://www.uniprot.org/uniprot/BAG1_HUMAN BAG1_HUMAN]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9305631</ref> <ref>PMID:9873016</ref> <ref>PMID:12724406</ref>
+
[https://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 32: Line 31:
==See Also==
==See Also==
-
*[[BAG protein|BAG protein]]
+
*[[BAG family proteins 3D structures|BAG family proteins 3D structures]]
-
*[[Heat Shock Proteins|Heat Shock Proteins]]
+
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Dokurno, P]]
+
[[Category: Large Structures]]
-
[[Category: Murray, J B]]
+
[[Category: Dokurno P]]
-
[[Category: Surgenor, A E]]
+
[[Category: Murray JB]]
-
[[Category: Williamson, D S]]
+
[[Category: Surgenor AE]]
-
[[Category: Adenosine]]
+
[[Category: Williamson DS]]
-
[[Category: Apoptosis]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Bag1]]
+
-
[[Category: Chaperone]]
+
-
[[Category: Heat shock]]
+
-
[[Category: Hsc70]]
+
-
[[Category: Hsp70]]
+
-
[[Category: Nucleotide]]
+
-
[[Category: Nucleotide exchange factor]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Protein folding]]
+
-
[[Category: Small molecule inhibitor]]
+
-
[[Category: Stress response]]
+

Current revision

Crystal Structures of Hsc70/Bag1 in Complex with Small Molecule Inhibitors

PDB ID 3fzk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fzk"
Personal tools