This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3kcv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:11, 1 November 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3kcv| PDB=3kcv | SCENE= }}
 
-
===Structure of formate channel===
 
-
{{ABSTRACT_PUBMED_19940917}}
 
-
==Function==
+
==Structure of formate channel==
-
[[http://www.uniprot.org/uniprot/FOCA_ECO57 FOCA_ECO57]] Involved in the bidirectional transport of formate (By similarity).
+
<StructureSection load='3kcv' size='340' side='right'caption='[[3kcv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3kcv]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KCV FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.198&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kcv OCA], [https://pdbe.org/3kcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kcv RCSB], [https://www.ebi.ac.uk/pdbsum/3kcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kcv ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FOCA_ECO57 FOCA_ECO57] Involved in the bidirectional transport of formate (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/3kcv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kcv ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
FocA is a representative member of the formate-nitrite transporter family, which transports short-chain acids in bacteria, archaea, fungi, algae and parasites. The structure and transport mechanism of the formate-nitrite transporter family remain unknown. Here we report the crystal structure of Escherichia coli FocA at 2.25 A resolution. FocA forms a symmetric pentamer, with each protomer consisting of six transmembrane segments. Despite a lack of sequence homology, the overall structure of the FocA protomer closely resembles that of aquaporin and strongly argues that FocA is a channel, rather than a transporter. Structural analysis identifies potentially important channel residues, defines the channel path and reveals two constriction sites. Unlike aquaporin, FocA is impermeable to water but allows the passage of formate. A structural and biochemical investigation provides mechanistic insights into the channel activity of FocA.
-
==About this Structure==
+
Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel.,Wang Y, Huang Y, Wang J, Cheng C, Huang W, Lu P, Xu YN, Wang P, Yan N, Shi Y Nature. 2009 Nov 26;462(7272):467-72. PMID:19940917<ref>PMID:19940917</ref>
-
[[3kcv]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco57 Eco57]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCV OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:019940917</ref><references group="xtra"/><references/>
+
</div>
-
[[Category: Eco57]]
+
<div class="pdbe-citations 3kcv" style="background-color:#fffaf0;"></div>
-
[[Category: Huang, Y.]]
+
== References ==
-
[[Category: Shi, Y.]]
+
<references/>
-
[[Category: Wang, J.]]
+
__TOC__
-
[[Category: Wang, Y.]]
+
</StructureSection>
-
[[Category: Yan, N.]]
+
[[Category: Escherichia coli O157:H7]]
-
[[Category: Cell inner membrane]]
+
[[Category: Large Structures]]
-
[[Category: Cell membrane]]
+
[[Category: Huang Y]]
-
[[Category: Channel]]
+
[[Category: Shi Y]]
-
[[Category: Formate]]
+
[[Category: Wang J]]
-
[[Category: Membrane]]
+
[[Category: Wang Y]]
-
[[Category: Tcdb id 2 a.44 1.1]]
+
[[Category: Yan N]]
-
[[Category: Transmembrane]]
+
-
[[Category: Transport]]
+
-
[[Category: Transport protein]]
+
-
[[Category: Transporter]]
+

Current revision

Structure of formate channel

PDB ID 3kcv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3kcv"
Personal tools