This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3kcz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:11, 1 November 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor 3-aminobenzamide==
==Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor 3-aminobenzamide==
-
<StructureSection load='3kcz' size='340' side='right' caption='[[3kcz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+
<StructureSection load='3kcz' size='340' side='right'caption='[[3kcz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3kcz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KCZ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3kcz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KCZ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADPRT2, ADPRTL2, PARP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AB:3-AMINOBENZAMIDE'>3AB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kcz OCA], [https://pdbe.org/3kcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kcz RCSB], [https://www.ebi.ac.uk/pdbsum/3kcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kcz ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kcz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kcz RCSB], [http://www.ebi.ac.uk/pdbsum/3kcz PDBsum]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PARP2_HUMAN PARP2_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
+
[https://www.uniprot.org/uniprot/PARP2_HUMAN PARP2_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/3kcz_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/3kcz_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kcz ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 28: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 3kcz" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
+
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 36: Line 37:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Large Structures]]
-
[[Category: Berg, S Van Den]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Berglund, H]]
+
[[Category: Berglund H]]
-
[[Category: Bountra, C]]
+
[[Category: Bountra C]]
-
[[Category: Collins, R]]
+
[[Category: Collins R]]
-
[[Category: Edwards, A M]]
+
[[Category: Edwards AM]]
-
[[Category: Flodin, S]]
+
[[Category: Flodin S]]
-
[[Category: Flores, A]]
+
[[Category: Flores A]]
-
[[Category: Graslund, S]]
+
[[Category: Graslund S]]
-
[[Category: Hammarstrom, M]]
+
[[Category: Hammarstrom M]]
-
[[Category: Johansson, A]]
+
[[Category: Johansson A]]
-
[[Category: Johansson, I]]
+
[[Category: Johansson I]]
-
[[Category: Kallas, A]]
+
[[Category: Kallas A]]
-
[[Category: Karlberg, T]]
+
[[Category: Karlberg T]]
-
[[Category: Kotenyova, T]]
+
[[Category: Kotenyova T]]
-
[[Category: Kotzsch, A]]
+
[[Category: Kotzsch A]]
-
[[Category: Kraulis, P]]
+
[[Category: Kraulis P]]
-
[[Category: Moche, M]]
+
[[Category: Moche M]]
-
[[Category: Nielsen, T K]]
+
[[Category: Nielsen TK]]
-
[[Category: Nordlund, P]]
+
[[Category: Nordlund P]]
-
[[Category: Nyman, T]]
+
[[Category: Nyman T]]
-
[[Category: Persson, C]]
+
[[Category: Persson C]]
-
[[Category: Roos, A K]]
+
[[Category: Roos AK]]
-
[[Category: Structural genomic]]
+
[[Category: Schuler H]]
-
[[Category: Schuler, H]]
+
[[Category: Schutz P]]
-
[[Category: Schutz, P]]
+
[[Category: Siponen MI]]
-
[[Category: Siponen, M I]]
+
[[Category: Thorsell AG]]
-
[[Category: Thorsell, A G]]
+
[[Category: Tresaugues L]]
-
[[Category: Tresaugues, L]]
+
[[Category: Van Den Berg S]]
-
[[Category: Weigelt, J]]
+
[[Category: Weigelt J]]
-
[[Category: Welin, M]]
+
[[Category: Welin M]]
-
[[Category: Wisniewska, M]]
+
[[Category: Wisniewska M]]
-
[[Category: Catalytic fragment]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Enzyme-inhibitor complex]]
+
-
[[Category: Glycosyltransferase]]
+
-
[[Category: Nad]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Sgc]]
+
-
[[Category: Transferase]]
+

Current revision

Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor 3-aminobenzamide

PDB ID 3kcz

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3kcz"
Personal tools