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3lci

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==The D-sialic acid aldolase mutant V251W==
==The D-sialic acid aldolase mutant V251W==
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<StructureSection load='3lci' size='340' side='right' caption='[[3lci]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
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<StructureSection load='3lci' size='340' side='right'caption='[[3lci]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lci]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LCI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lci]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LCI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nal|1nal]], [[3lbc|3lbc]], [[3lbm|3lbm]], [[3lcf|3lcf]], [[3lcg|3lcg]], [[3lch|3lch]], [[3lcl|3lcl]], [[3lcw|3lcw]], [[3lcx|3lcx]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b3225, JW3194, nanA, npl ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lci OCA], [https://pdbe.org/3lci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lci RCSB], [https://www.ebi.ac.uk/pdbsum/3lci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lci ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lci OCA], [http://pdbe.org/3lci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lci RCSB], [http://www.ebi.ac.uk/pdbsum/3lci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lci ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NANA_ECOLI NANA_ECOLI]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237]
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[https://www.uniprot.org/uniprot/NANA_ECOLI NANA_ECOLI] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237]
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==See Also==
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*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: N-acetylneuraminate lyase]]
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[[Category: Large Structures]]
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[[Category: Chou, C Y]]
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[[Category: Chou C-Y]]
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[[Category: Ko, T P]]
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[[Category: Ko T-P]]
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[[Category: Wang, A H.J]]
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[[Category: Wang AH-J]]
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[[Category: Carbohydrate metabolism]]
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[[Category: Lyase]]
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[[Category: Schiff base]]
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[[Category: Tim barrel]]
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The D-sialic acid aldolase mutant V251W

PDB ID 3lci

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