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3lkx

From Proteopedia

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Current revision (16:24, 1 November 2023) (edit) (undo)
 
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==Human nac dimerization domain==
==Human nac dimerization domain==
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<StructureSection load='3lkx' size='340' side='right' caption='[[3lkx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3lkx' size='340' side='right'caption='[[3lkx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LKX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lkx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LKX FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NACA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), BTF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lkx OCA], [http://pdbe.org/3lkx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lkx RCSB], [http://www.ebi.ac.uk/pdbsum/3lkx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lkx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lkx OCA], [https://pdbe.org/3lkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lkx RCSB], [https://www.ebi.ac.uk/pdbsum/3lkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lkx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BTF3_HUMAN BTF3_HUMAN]] General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription. [[http://www.uniprot.org/uniprot/NACA_HUMAN NACA_HUMAN]] Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.<ref>PMID:9877153</ref> <ref>PMID:10982809</ref> <ref>PMID:15784678</ref>
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[https://www.uniprot.org/uniprot/BTF3_HUMAN BTF3_HUMAN] General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lk/3lkx_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lk/3lkx_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3lkx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3lkx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[NAC transcription factor|NAC transcription factor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Hu, Y]]
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[[Category: Large Structures]]
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[[Category: Li, X]]
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[[Category: Hu Y]]
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[[Category: Liu, Y]]
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[[Category: Li X]]
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[[Category: Niu, L]]
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[[Category: Liu Y]]
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[[Category: Teng, M]]
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[[Category: Niu L]]
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[[Category: Beta-barrel]]
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[[Category: Teng M]]
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[[Category: Chaperone]]
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Current revision

Human nac dimerization domain

PDB ID 3lkx

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