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3m8o

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{{STRUCTURE_3m8o| PDB=3m8o | SCENE= }}
 
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===Human IgA1 Fab fragment===
 
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{{ABSTRACT_PUBMED_23519414}}
 
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==About this Structure==
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==Human IgA1 Fab fragment==
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[[3m8o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8O OCA].
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<StructureSection load='3m8o' size='340' side='right'caption='[[3m8o]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M8O FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8o OCA], [https://pdbe.org/3m8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m8o RCSB], [https://www.ebi.ac.uk/pdbsum/3m8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8o ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Despite being the most abundant class of immunoglobulins in humans and playing central roles in the adaptive immune response, high-resolution structural data are still lacking for the antigen-binding region of human isotype A antibodies (IgAs). The crystal structures of a human Fab fragment of IgA1 in three different crystal forms are now reported. The three-dimensional organization is similar to those of other Fab classes, but FabA1 seems to be more rigid, being constrained by a hydrophobic core in the interface between the variable and constant domains of the heavy chain (VH-CH1) as well as by a disulfide bridge that connects the light and heavy chains, influencing the relative heavy/light-chain orientation. The crystal structure of the same antibody but with a G-isotype CH1 which is reported to display different antigen affinity has also been solved. The differential structural features reveal plausible mechanisms for constant/variable-domain long-distance effects whereby antibody class switching could alter antigen affinity.
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==Reference==
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Structure of a human IgA1 Fab fragment at 1.55 A resolution: potential effect of the constant domains on antigen-affinity modulation.,Correa A, Trajtenberg F, Obal G, Pritsch O, Dighiero G, Oppezzo P, Buschiazzo A Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):388-97. doi:, 10.1107/S0907444912048664. Epub 2013 Feb 16. PMID:23519414<ref>PMID:23519414</ref>
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<ref group="xtra">PMID:023519414</ref><references group="xtra"/><references/>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3m8o" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Buschiazzo, A.]]
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[[Category: Large Structures]]
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[[Category: Correa, A.]]
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[[Category: Buschiazzo A]]
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[[Category: Dighiero, G.]]
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[[Category: Correa A]]
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[[Category: Oppezzo, P.]]
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[[Category: Dighiero G]]
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[[Category: Pritsch, O.]]
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[[Category: Oppezzo P]]
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[[Category: Trajtenberg, F.]]
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[[Category: Pritsch O]]
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[[Category: Immune system]]
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[[Category: Trajtenberg F]]
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[[Category: Immunoglobulin fold]]
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Current revision

Human IgA1 Fab fragment

PDB ID 3m8o

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