1nyu

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[[Image:1nyu.gif|left|200px]]
[[Image:1nyu.gif|left|200px]]
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{{Structure
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|PDB= 1nyu |SIZE=350|CAPTION= <scene name='initialview01'>1nyu</scene>, resolution 3.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1nyu", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= actrIIb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), INHBA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1nyu| PDB=1nyu | SCENE= }}
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|RELATEDENTRY=[[1nys|1NYS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nyu OCA], [http://www.ebi.ac.uk/pdbsum/1nyu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nyu RCSB]</span>
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'''Crystal Structure of Activin A Bound to the ECD of ActRIIB'''
'''Crystal Structure of Activin A Bound to the ECD of ActRIIB'''
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[[Category: Thompson, T B.]]
[[Category: Thompson, T B.]]
[[Category: Woodruff, T K.]]
[[Category: Woodruff, T K.]]
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[[Category: activin]]
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[[Category: Activin]]
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[[Category: actriib]]
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[[Category: Actriib]]
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[[Category: extracellular domain]]
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[[Category: Extracellular domain]]
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[[Category: tgf beta]]
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[[Category: Tgf beta]]
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[[Category: type ii]]
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[[Category: Type ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:09:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:37:24 2008''
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Revision as of 00:09, 3 May 2008

Image:1nyu.gif

Template:STRUCTURE 1nyu

Crystal Structure of Activin A Bound to the ECD of ActRIIB


Overview

The TGF-beta superfamily of ligands and receptors stimulate cellular events in diverse processes ranging from cell fate specification in development to immune suppression. Activins define a major subgroup of TGF-beta ligands that regulate cellular differentiation, proliferation, activation and apoptosis. Activins signal through complexes formed with type I and type II serine/threonine kinase receptors. We have solved the crystal structure of activin A bound to the extracellular domain of a type II receptor, ActRIIB, revealing the details of this interaction. ActRIIB binds to the outer edges of the activin finger regions, with the two receptors juxtaposed in close proximity, in a mode that differs from TGF-beta3 binding to type II receptors. The dimeric activin A structure differs from other known TGF-beta ligand structures, adopting a compact folded-back conformation. The crystal structure of the complex is consistent with recruitment of two type I receptors into a close packed arrangement at the cell surface and suggests that diversity in the conformational arrangements of TGF-beta ligand dimers could influence cellular signaling processes.

About this Structure

1NYU is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions., Thompson TB, Woodruff TK, Jardetzky TS, EMBO J. 2003 Apr 1;22(7):1555-66. PMID:12660162 Page seeded by OCA on Sat May 3 03:09:11 2008

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