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3mk3

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==Crystal structure of Lumazine synthase from Salmonella typhimurium LT2==
==Crystal structure of Lumazine synthase from Salmonella typhimurium LT2==
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<StructureSection load='3mk3' size='340' side='right' caption='[[3mk3]], [[Resolution|resolution]] 3.57&Aring;' scene=''>
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<StructureSection load='3mk3' size='340' side='right'caption='[[3mk3]], [[Resolution|resolution]] 3.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mk3]] is a 60 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MK3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mk3]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MK3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.569&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ribH, STM0417 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mk3 OCA], [https://pdbe.org/3mk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mk3 RCSB], [https://www.ebi.ac.uk/pdbsum/3mk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mk3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mk3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mk3 RCSB], [http://www.ebi.ac.uk/pdbsum/3mk3 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RISB_SALTY RISB_SALTY]] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity).
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[https://www.uniprot.org/uniprot/RISB_SALTY RISB_SALTY] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3mk3" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]
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[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Karthikeyan, S]]
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[[Category: Karthikeyan S]]
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[[Category: Kumar, P]]
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[[Category: Kumar P]]
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[[Category: Singh, M]]
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[[Category: Singh M]]
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[[Category: Dmrl synthase]]
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[[Category: Drug target]]
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[[Category: Flavodoxin like fold]]
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[[Category: Icosahedral]]
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[[Category: Riboflavin biosynthesis]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Lumazine synthase from Salmonella typhimurium LT2

PDB ID 3mk3

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