This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3mnn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:35, 1 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core==
==A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core==
-
<StructureSection load='3mnn' size='340' side='right' caption='[[3mnn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+
<StructureSection load='3mnn' size='340' side='right'caption='[[3mnn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3mnn]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MNN FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3mnn]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MNN FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MML:1-METHYL-4-(1-METHYLETHYL)BENZENE'>MML</scene>, <scene name='pdbligand=PTW:1,3,5-TRIAZA-7-PHOSPHATRICYCLO[3.3.1.1~3,7~]DECANE'>PTW</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nzd|2nzd]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MML:1-METHYL-4-(1-METHYLETHYL)BENZENE'>MML</scene>, <scene name='pdbligand=PTW:1,3,5-TRIAZA-7-PHOSPHATRICYCLO[3.3.1.1~3,7~]DECANE'>PTW</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HISTONE H3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), HISTONE H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), HISTONE H2A, LOC494591 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog]), HISTONE H2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mnn OCA], [https://pdbe.org/3mnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mnn RCSB], [https://www.ebi.ac.uk/pdbsum/3mnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mnn ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mnn OCA], [http://pdbe.org/3mnn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mnn RCSB], [http://www.ebi.ac.uk/pdbsum/3mnn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mnn ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
+
[https://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 +
 
 +
==See Also==
 +
*[[Histone 3D structures|Histone 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: African clawed frog]]
+
[[Category: Large Structures]]
-
[[Category: Davey, C A]]
+
[[Category: Xenopus laevis]]
-
[[Category: Ong, M S]]
+
[[Category: Davey CA]]
-
[[Category: Ncp]]
+
[[Category: Ong MS]]
-
[[Category: Nucleosome]]
+
-
[[Category: Rapta-c]]
+
-
[[Category: Ruthenium]]
+
-
[[Category: Structural protein-dna complex]]
+

Current revision

A Ruthenium Antitumour Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

PDB ID 3mnn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3mnn"
Personal tools