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3n2e

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==Crystal structure of Helicobactor pylori shikimate kinase in complex with NSC162535==
==Crystal structure of Helicobactor pylori shikimate kinase in complex with NSC162535==
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<StructureSection load='3n2e' size='340' side='right' caption='[[3n2e]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
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<StructureSection load='3n2e' size='340' side='right'caption='[[3n2e]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3n2e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N2E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3n2e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N2E FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OSA:7-AMINO-4-HYDROXY-3-[(E)-(5-HYDROXY-7-SULFONAPHTHALEN-2-YL)DIAZENYL]NAPHTHALENE-2-SULFONIC+ACID'>OSA</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zuh|1zuh]], [[1zui|1zui]], [[3hr7|3hr7]], [[3mrs|3mrs]], [[3muf|3muf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OSA:7-AMINO-4-HYDROXY-3-[(E)-(5-HYDROXY-7-SULFONAPHTHALEN-2-YL)DIAZENYL]NAPHTHALENE-2-SULFONIC+ACID'>OSA</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aroK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=210 Helicobacter pylori])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n2e OCA], [https://pdbe.org/3n2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n2e RCSB], [https://www.ebi.ac.uk/pdbsum/3n2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n2e ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_kinase Shikimate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.71 2.7.1.71] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n2e RCSB], [http://www.ebi.ac.uk/pdbsum/3n2e PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/AROK_HELPY AROK_HELPY] Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.<ref>PMID:16291688</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.,Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM, Wang WC PLoS One. 2012;7(3):e33481. Epub 2012 Mar 16. PMID:22438938<ref>PMID:22438938</ref>
Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism.,Cheng WC, Chen YF, Wang HJ, Hsu KC, Lin SC, Chen TJ, Yang JM, Wang WC PLoS One. 2012;7(3):e33481. Epub 2012 Mar 16. PMID:22438938<ref>PMID:22438938</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3n2e" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Shikimate kinase 3D structures|Shikimate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Helicobacter pylori]]
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[[Category: Helicobacter pylori 26695]]
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[[Category: Shikimate kinase]]
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[[Category: Large Structures]]
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[[Category: Chen, T J.]]
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[[Category: Chen TJ]]
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[[Category: Cheng, W C.]]
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[[Category: Cheng WC]]
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[[Category: Lin, S C.]]
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[[Category: Lin SC]]
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[[Category: Wang, W C.]]
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[[Category: Wang WC]]
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[[Category: Alpha-beta-alpha fold]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Helicobactor pylori shikimate kinase in complex with NSC162535

PDB ID 3n2e

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