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3nd7

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==Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine==
==Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine==
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<StructureSection load='3nd7' size='340' side='right' caption='[[3nd7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3nd7' size='340' side='right'caption='[[3nd7]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nd7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ND7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ND7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nd7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ND7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ND7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PNY:(2R)-2,4-DIHYDROXY-3,3-DIMETHYL-N-{3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}BUTANAMIDE'>PNY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nd5|3nd5]], [[3nd6|3nd6]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PNY:(2R)-2,4-DIHYDROXY-3,3-DIMETHYL-N-{3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}BUTANAMIDE'>PNY</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">coaD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nd7 OCA], [https://pdbe.org/3nd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nd7 RCSB], [https://www.ebi.ac.uk/pdbsum/3nd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nd7 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nd7 RCSB], [http://www.ebi.ac.uk/pdbsum/3nd7 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/COAD_ENTFA COAD_ENTFA]] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
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[https://www.uniprot.org/uniprot/COAD_ENTFA COAD_ENTFA] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3nd7" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
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[[Category: Pantetheine-phosphate adenylyltransferase]]
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[[Category: Large Structures]]
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[[Category: Lee, H H]]
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[[Category: Lee HH]]
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[[Category: Suh, S W]]
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[[Category: Suh SW]]
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[[Category: Yoon, H J]]
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[[Category: Yoon HJ]]
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[[Category: Coenzyme a biosynthetic pathway]]
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[[Category: Phosphopantetheine adenylyltransferase]]
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[[Category: Ppat]]
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[[Category: Transferase]]
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Current revision

Crystal structure of phosphopantetheine adenylyltransferase from Enterococcus faecalis in the ligand-unbound state and in complex with ATP and pantetheine

PDB ID 3nd7

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