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3niu

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{{Seed}}
 
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[[Image:3niu.jpg|left|200px]]
 
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==Crystal structure of the complex of dimeric goat lactoperoxidase with diethylene glycol at 2.9 A resolution==
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The line below this paragraph, containing "STRUCTURE_3niu", creates the "Structure Box" on the page.
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<StructureSection load='3niu' size='340' side='right'caption='[[3niu]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3niu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NIU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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{{STRUCTURE_3niu| PDB=3niu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3niu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3niu OCA], [https://pdbe.org/3niu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3niu RCSB], [https://www.ebi.ac.uk/pdbsum/3niu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3niu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PERL_CAPHI PERL_CAPHI] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).<ref>PMID:10894086</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ni/3niu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3niu ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the complex of dimeric goat lactoperoxidase with diethylene glycol at 2.9 A resolution===
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==See Also==
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*[[Lactoperoxidase|Lactoperoxidase]]
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== References ==
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==About this Structure==
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<references/>
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3NIU is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIU OCA].
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__TOC__
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</StructureSection>
[[Category: Capra hircus]]
[[Category: Capra hircus]]
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[[Category: Peroxidase]]
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[[Category: Large Structures]]
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[[Category: Kaur, P.]]
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[[Category: Kaur P]]
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[[Category: Sharma, S.]]
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[[Category: Sharma S]]
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[[Category: Singh, A K.]]
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[[Category: Singh AK]]
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[[Category: Singh, R P.]]
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[[Category: Singh RP]]
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[[Category: Singh, T P.]]
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[[Category: Singh TP]]
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[[Category: Sinha, M.]]
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[[Category: Sinha M]]
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[[Category: Vikram, G.]]
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[[Category: Vikram G]]
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[[Category: Complex]]
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[[Category: Diethylene glycol]]
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[[Category: Lactoperoxidase]]
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[[Category: Metal binding protein]]
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[[Category: Milk protein]]
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[[Category: Oxidoreductase]]
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[[Category: Phosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:23:24 2010''
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Current revision

Crystal structure of the complex of dimeric goat lactoperoxidase with diethylene glycol at 2.9 A resolution

PDB ID 3niu

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