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3np6

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[[Image:3np6.png|left|200px]]
 
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==The crystal structure of Berberine bound to DNA d(CGTACG)==
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The line below this paragraph, containing "STRUCTURE_3np6", creates the "Structure Box" on the page.
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<StructureSection load='3np6' size='340' side='right'caption='[[3np6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3np6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NP6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BER:BERBERINE'>BER</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3np6| PDB=3np6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3np6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3np6 OCA], [https://pdbe.org/3np6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3np6 RCSB], [https://www.ebi.ac.uk/pdbsum/3np6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3np6 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 A resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form.
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===The crystal structure of Berberine bound to DNA d(CGTACG)===
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X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).,Ferraroni M, Bazzicalupi C, Bilia AR, Gratteri P Chem Commun (Camb). 2011 May 7;47(17):4917-9. Epub 2011 Mar 22. PMID:21431128<ref>PMID:21431128</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3np6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21431128 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21431128}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3np6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NP6 OCA].
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[[Category: Bazzicalupi C]]
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[[Category: Bilia AR]]
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==Reference==
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[[Category: Ferraroni M]]
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<ref group="xtra">PMID:021431128</ref><references group="xtra"/>
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[[Category: Gratteri P]]
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[[Category: Bazzicalupi, C.]]
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[[Category: Bilia, A R.]]
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[[Category: Ferraroni, M.]]
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[[Category: Gratteri, P.]]
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[[Category: B-dna]]
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[[Category: Dna]]
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[[Category: Double helix]]
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[[Category: Drug-dna complex]]
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Current revision

The crystal structure of Berberine bound to DNA d(CGTACG)

PDB ID 3np6

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