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3nti
From Proteopedia
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| - | {{STRUCTURE_3nti| PDB=3nti | SCENE= }} | ||
| - | ===Crystal structure of Tudor and Aubergine [R15(me2s)] complex=== | ||
| - | {{ABSTRACT_PUBMED_20713507}} | ||
| - | == | + | ==Crystal structure of Tudor and Aubergine [R15(me2s)] complex== |
| - | [[http://www.uniprot.org/uniprot/TUD_DROME TUD_DROME | + | <StructureSection load='3nti' size='340' side='right'caption='[[3nti]], [[Resolution|resolution]] 2.80Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3nti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NTI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nti OCA], [https://pdbe.org/3nti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nti RCSB], [https://www.ebi.ac.uk/pdbsum/3nti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nti ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TUD_DROME TUD_DROME] Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/3nti_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nti ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Piwi proteins are modified by symmetric dimethylation of arginine (sDMA), and the methylarginine-dependent interaction with Tudor domain proteins is critical for their functions in germline development. Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage. Furthermore, the unexpected Tudor-SN/p100 fold of eTud is important for sensing the position of sDMA. The structural information provides mechanistic insights into sDMA-dependent Piwi-Tudor interaction, and the recognition of sDMA by Tudor domains in general. | ||
| - | + | Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.,Liu H, Wang JY, Huang Y, Li Z, Gong W, Lehmann R, Xu RM Genes Dev. 2010 Sep 1;24(17):1876-81. Epub 2010 Aug 16. PMID:20713507<ref>PMID:20713507</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | < | + | </div> |
| + | <div class="pdbe-citations 3nti" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Gong WM]] |
| - | [[Category: | + | [[Category: Huang Y]] |
| - | [[Category: | + | [[Category: Li ZZ]] |
| - | [[Category: | + | [[Category: Liu HP]] |
| - | [[Category: | + | [[Category: Xu RM]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of Tudor and Aubergine [R15(me2s)] complex
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Categories: Drosophila melanogaster | Large Structures | Gong WM | Huang Y | Li ZZ | Liu HP | Xu RM
