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3o19

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[[Image:3o19.png|left|200px]]
 
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{{STRUCTURE_3o19| PDB=3o19 | SCENE= }}
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==Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid==
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<StructureSection load='3o19' size='340' side='right'caption='[[3o19]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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===Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3o19]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O19 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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[[3o19]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O19 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o19 OCA], [https://pdbe.org/3o19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o19 RCSB], [https://www.ebi.ac.uk/pdbsum/3o19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o19 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTGDS_HUMAN PTGDS_HUMAN] Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.<ref>PMID:9475419</ref> <ref>PMID:20667974</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o1/3o19_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o19 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Prostaglandin D synthase|Prostaglandin D synthase]]
*[[Prostaglandin D synthase|Prostaglandin D synthase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Prostaglandin-D synthase]]
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[[Category: Large Structures]]
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[[Category: Li, Y.]]
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[[Category: Li Y]]
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[[Category: Liu, Z J.]]
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[[Category: Liu Z-J]]
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[[Category: Shaw, N.]]
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[[Category: Shaw N]]
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[[Category: Zhang, R.]]
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[[Category: Zhang R]]
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[[Category: Zhao, Y.]]
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[[Category: Zhao Y]]
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[[Category: Zhou, Y.]]
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[[Category: Zhou Y]]
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[[Category: Isomerase]]
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[[Category: Lipocalin]]
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[[Category: Prostaglandin synthase]]
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Current revision

Structure-function analysis of human L-Prostaglandin D Synthase bound with fatty acid

PDB ID 3o19

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