This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3pz8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:09, 1 November 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3pz8| PDB=3pz8 | SCENE= }}
 
-
===Crystal structure of Dvl1-DIX(Y17D) mutant===
 
-
{{ABSTRACT_PUBMED_021189423}}
 
-
==Function==
+
==Crystal structure of Dvl1-DIX(Y17D) mutant==
-
[[http://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE]] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref>
+
<StructureSection load='3pz8' size='340' side='right'caption='[[3pz8]], [[Resolution|resolution]] 2.87&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[3pz8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ8 FirstGlance]. <br>
-
[[3pz8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ8 OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.873&#8491;</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz8 OCA], [https://pdbe.org/3pz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz8 ProSAT]</span></td></tr>
-
==Reference==
+
</table>
-
<ref group="xtra">PMID:021189423</ref><references group="xtra"/><references/>
+
== Function ==
 +
[https://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Chen, L.]]
+
[[Category: Chen L]]
-
[[Category: Dan, Q J.]]
+
[[Category: Dan QJ]]
-
[[Category: Liu, Y T.]]
+
[[Category: Liu YT]]
-
[[Category: Wu, J W.]]
+
[[Category: Wu JW]]
-
[[Category: Zhang, Y Y.]]
+
[[Category: Zhang YY]]
-
[[Category: Dix domain]]
+
-
[[Category: Oligomerization]]
+
-
[[Category: Signaling protein]]
+

Current revision

Crystal structure of Dvl1-DIX(Y17D) mutant

PDB ID 3pz8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3pz8"
Personal tools