This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3pz8
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
==Crystal structure of Dvl1-DIX(Y17D) mutant== | ==Crystal structure of Dvl1-DIX(Y17D) mutant== | ||
| - | <StructureSection load='3pz8' size='340' side='right' caption='[[3pz8]], [[Resolution|resolution]] 2.87Å' scene=''> | + | <StructureSection load='3pz8' size='340' side='right'caption='[[3pz8]], [[Resolution|resolution]] 2.87Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3pz8]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3pz8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PZ8 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.873Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pz8 OCA], [https://pdbe.org/3pz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pz8 RCSB], [https://www.ebi.ac.uk/pdbsum/3pz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pz8 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DVL1_MOUSE DVL1_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).<ref>PMID:12165471</ref> <ref>PMID:15353129</ref> <ref>PMID:11101902</ref> <ref>PMID:19637179</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Chen L]] |
| - | [[Category: | + | [[Category: Dan QJ]] |
| - | [[Category: | + | [[Category: Liu YT]] |
| - | [[Category: | + | [[Category: Wu JW]] |
| - | [[Category: | + | [[Category: Zhang YY]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of Dvl1-DIX(Y17D) mutant
| |||||||||||
Categories: Large Structures | Mus musculus | Chen L | Dan QJ | Liu YT | Wu JW | Zhang YY
