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3q2c

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[[Image:3q2c.jpg|left|200px]]
 
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==Binding properties to HLA class I molecules and the structure of the leukocyte Ig-like receptor A3 (LILRA3/ILT6/LIR4/CD85e)==
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The line below this paragraph, containing "STRUCTURE_3q2c", creates the "Structure Box" on the page.
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<StructureSection load='3q2c' size='340' side='right'caption='[[3q2c]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3q2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2c OCA], [https://pdbe.org/3q2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2c RCSB], [https://www.ebi.ac.uk/pdbsum/3q2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2c ProSAT]</span></td></tr>
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{{STRUCTURE_3q2c| PDB=3q2c | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LIRA3_HUMAN LIRA3_HUMAN] Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes.<ref>PMID:21559424</ref> <ref>PMID:24085305</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Structurally, Group 1 LILR (Leukocyte Immunoglobulin (Ig)-Like Receptor, also known as Ig-like transcripts, ILT; Leukocyte Ig-like receptor, LIR; and CD85) members are very similar in terms of the HLAIs (human leukocyte antigen class I molecules) binding region and were hypothesized that they all bind to HLAIs. As one of the Group 1 LILRs, LILRA3 is the only secretory LILR and may greatly control the inhibitory immune response induced by LILRB1, LILRB2, and other HLA-binding LILR molecules like LILRA1. Nevertheless, little was known about the binding of LILRA3 to HLAIs. In this report, we present the crystal structure of the LILRA3 domain 1 (D1) and evaluate the D1 and D1D2 (domain 1 and domain 2) binding to classical and non-classical HLAIs using BIAcore(R) surface plasmon resonance analysis (SPR). We found that LILRA3 binds both classical HLA-A*0201 and non-classical HLA-G1 but with reduced affinities compared to either LILRB1 or LILRB2. The polymorphic amino acids and the LILRA3 D1 structure support this notion.
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===Binding properties to HLA class I molecules and the structure of the leukocyte Ig-like receptor A3 (LILRA3/ILT6/LIR4/CD85e)===
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LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.,Ryu M, Chen Y, Qi J, Liu J, Fan Z, Nam G, Shi Y, Cheng H, Gao GF PLoS One. 2011 Apr 29;6(4):e19245. PMID:21559424<ref>PMID:21559424</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3q2c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Leukocyte immunoglobulin-like receptor|Leukocyte immunoglobulin-like receptor]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21559424 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21559424}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3q2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2C OCA].
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==Reference==
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<ref group="xtra">PMID:021559424</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, Y.]]
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[[Category: Large Structures]]
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[[Category: Cheng, H.]]
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[[Category: Chen Y]]
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[[Category: Gao, G F.]]
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[[Category: Cheng H]]
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[[Category: Liu, J.]]
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[[Category: Gao GF]]
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[[Category: Qi, J X.]]
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[[Category: Liu J]]
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[[Category: Ryu, M.]]
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[[Category: Qi JX]]
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[[Category: Shi, Y.]]
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[[Category: Ryu M]]
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[[Category: Activating receptor]]
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[[Category: Shi Y]]
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[[Category: Hla binding]]
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[[Category: Ilt6]]
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[[Category: Immune system]]
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[[Category: Lilra3]]
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Current revision

Binding properties to HLA class I molecules and the structure of the leukocyte Ig-like receptor A3 (LILRA3/ILT6/LIR4/CD85e)

PDB ID 3q2c

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