3qwa

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[[Image:3qwa.jpg|left|200px]]
 
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==Crystal structure of Saccharomyces cerevisiae Zeta-crystallin-like quinone oxidoreductase Zta1==
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The line below this paragraph, containing "STRUCTURE_3qwa", creates the "Structure Box" on the page.
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<StructureSection load='3qwa' size='340' side='right'caption='[[3qwa]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3qwa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QWA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qwa OCA], [https://pdbe.org/3qwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qwa RCSB], [https://www.ebi.ac.uk/pdbsum/3qwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qwa ProSAT]</span></td></tr>
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{{STRUCTURE_3qwa| PDB=3qwa | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/QOR_YEAST QOR_YEAST]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Quinone oxidoreductase (QOR EC1.6.5.5) catalyzes the reduction of quinone to hydroxyquinone using NADPH as a cofactor. Here we present the crystal structure of the zeta-crystallin-like QOR Zta1 from Saccharomycescerevisiae in apo-form at 2.00 A and complexed with NADPH at 1.59 A resolution. Zta1 forms a homodimer, with each subunit containing a catalytic and a cofactor-binding domain. Upon NADPH binding to the interdomain cleft, the two domains shift towards each other, producing a better fit for NADPH, and tightening substrate binding. Computational simulation combined with site-directed mutagenesis and enzymatic activity analysis defined a potential quinone-binding site that determines the stringent substrate specificity. Moreover, multiple-sequence alignment and kinetics assays implied that a single-residue change from Arg in lower organisms to Gly in vertebrates possibly resulted in elevation of enzymatic activity of zeta-crystallin-like QORs throughout evolution.
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===Crystal structure of Saccharomyces cerevisiae Zeta-crystallin-like quinone oxidoreductase Zta1===
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Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1.,Guo PC, Ma XX, Bao ZZ, Ma JD, Chen Y, Zhou CZ J Struct Biol. 2011 Oct;176(1):112-8. Epub 2011 Jul 26. PMID:21820057<ref>PMID:21820057</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3qwa" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21820057 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21820057}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3qwa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QWA OCA].
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Bao ZZ]]
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==Reference==
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[[Category: Chen YX]]
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<ref group="xtra">PMID:021820057</ref><references group="xtra"/>
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[[Category: Guo PC]]
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[[Category: NADPH:quinone reductase]]
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[[Category: Ma XX]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Zhou CZ]]
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[[Category: Bao, Z Z.]]
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[[Category: Chen, Y X.]]
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[[Category: Guo, P C.]]
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[[Category: Ma, X X.]]
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[[Category: Zhou, C Z.]]
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[[Category: Cytoplasm and nucleus]]
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[[Category: Nadph binding]]
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[[Category: Oxidoreductase]]
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[[Category: Quinone oxidoreductase]]
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[[Category: Rossmann fold]]
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Current revision

Crystal structure of Saccharomyces cerevisiae Zeta-crystallin-like quinone oxidoreductase Zta1

PDB ID 3qwa

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