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3spl

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==Crystal structure of aprataxin ortholog Hnt3 in complex with DNA and AMP==
==Crystal structure of aprataxin ortholog Hnt3 in complex with DNA and AMP==
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<StructureSection load='3spl' size='340' side='right' caption='[[3spl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3spl' size='340' side='right'caption='[[3spl]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3spl]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Fission_yeast Fission yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SPL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3spl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SPL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.101&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sp4|3sp4]], [[3spd|3spd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hnt3, SPCC18.09c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284812 Fission yeast])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3spl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3spl OCA], [https://pdbe.org/3spl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3spl RCSB], [https://www.ebi.ac.uk/pdbsum/3spl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3spl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3spl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3spl OCA], [http://pdbe.org/3spl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3spl RCSB], [http://www.ebi.ac.uk/pdbsum/3spl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3spl ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/APTX_SCHPO APTX_SCHPO]] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity).
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[https://www.uniprot.org/uniprot/APTX_SCHPO APTX_SCHPO] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fission yeast]]
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[[Category: Large Structures]]
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[[Category: Ding, J]]
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[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Dou, C]]
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[[Category: Ding J]]
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[[Category: Gong, Y]]
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[[Category: Dou C]]
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[[Category: Jiang, T]]
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[[Category: Gong Y]]
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[[Category: Ren, X]]
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[[Category: Jiang T]]
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[[Category: Wang, D]]
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[[Category: Ren X]]
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[[Category: Zhu, D]]
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[[Category: Wang D]]
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[[Category: Amp binding]]
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[[Category: Zhu D]]
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[[Category: Dna binding]]
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[[Category: Dna deadenylase]]
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[[Category: Hit domain]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Zinc finger]]
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Current revision

Crystal structure of aprataxin ortholog Hnt3 in complex with DNA and AMP

PDB ID 3spl

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