This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ttr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:33, 1 November 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of C-lobe of bovine lactoferrin complexed with Lidocaine at 2.27 A resolution==
==Crystal structure of C-lobe of bovine lactoferrin complexed with Lidocaine at 2.27 A resolution==
-
<StructureSection load='3ttr' size='340' side='right' caption='[[3ttr]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
+
<StructureSection load='3ttr' size='340' side='right'caption='[[3ttr]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3ttr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TTR FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3ttr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TTR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TTR FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LQZ:2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ETHANAMIDE'>LQZ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o97|3o97]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=LQZ:2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)ETHANAMIDE'>LQZ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ttr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ttr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ttr RCSB], [http://www.ebi.ac.uk/pdbsum/3ttr PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ttr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ttr OCA], [https://pdbe.org/3ttr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ttr RCSB], [https://www.ebi.ac.uk/pdbsum/3ttr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ttr ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
==See Also==
==See Also==
*[[Lactoferrin|Lactoferrin]]
*[[Lactoferrin|Lactoferrin]]
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Gautam, L]]
+
[[Category: Large Structures]]
-
[[Category: Kaur, P]]
+
[[Category: Gautam L]]
-
[[Category: Sharma, S]]
+
[[Category: Kaur P]]
-
[[Category: Singh, A]]
+
[[Category: Sharma S]]
-
[[Category: Singh, T P]]
+
[[Category: Singh A]]
-
[[Category: Sinha, M]]
+
[[Category: Singh TP]]
-
[[Category: Yamini, S]]
+
[[Category: Sinha M]]
-
[[Category: C-lobe]]
+
[[Category: Yamini S]]
-
[[Category: Complex]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Lactoferrin]]
+
-
[[Category: Lidocaine]]
+

Current revision

Crystal structure of C-lobe of bovine lactoferrin complexed with Lidocaine at 2.27 A resolution

PDB ID 3ttr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ttr"
Personal tools