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3tz6

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==Crystal structure of Aspartate semialdehyde dehydrogenase Complexed With inhibitor SMCS (CYS) And Phosphate From Mycobacterium tuberculosis H37Rv==
==Crystal structure of Aspartate semialdehyde dehydrogenase Complexed With inhibitor SMCS (CYS) And Phosphate From Mycobacterium tuberculosis H37Rv==
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<StructureSection load='3tz6' size='340' side='right' caption='[[3tz6]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='3tz6' size='340' side='right'caption='[[3tz6]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3tz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZ6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3tz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TZ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3llg|3llg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">asd, MT3811, MTV025.056c, Rv3708c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tz6 OCA], [https://pdbe.org/3tz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tz6 RCSB], [https://www.ebi.ac.uk/pdbsum/3tz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tz6 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tz6 OCA], [http://pdbe.org/3tz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tz6 RCSB], [http://www.ebi.ac.uk/pdbsum/3tz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tz6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DHAS_MYCTU DHAS_MYCTU]] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:15752328</ref>
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[https://www.uniprot.org/uniprot/DHAS_MYCTU DHAS_MYCTU] Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.<ref>PMID:15752328</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3tz6" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3tz6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
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*[[Aspartate-semialdehyde dehydrogenase 3D structures|Aspartate-semialdehyde dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aspartate-semialdehyde dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Karthikeyan, S]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Tewari, R]]
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[[Category: Karthikeyan S]]
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[[Category: Vyas, R]]
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[[Category: Tewari R]]
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[[Category: Weiss, M S]]
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[[Category: Vyas R]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Weiss MS]]
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[[Category: Asa]]
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[[Category: Asadh]]
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[[Category: Asd]]
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[[Category: Dehydrogenase]]
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[[Category: Diaminopimelate biosynthesis]]
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[[Category: Lysine biosynthesis]]
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[[Category: Oxidoreductase]]
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[[Category: Smc]]
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Current revision

Crystal structure of Aspartate semialdehyde dehydrogenase Complexed With inhibitor SMCS (CYS) And Phosphate From Mycobacterium tuberculosis H37Rv

PDB ID 3tz6

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