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3u7m

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Current revision (17:35, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3u7m' size='340' side='right'caption='[[3u7m]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='3u7m' size='340' side='right'caption='[[3u7m]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_COL Staphylococcus aureus subsp. aureus COL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U7M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FHF:N-((2R,4S)-2-BUTYL-4-(3-(2-FLUOROPHENYL)UREIDO)-5-METHYL-3-OXOHEXYL)-N-HYDROXYFORMAMIDE'>FHF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=FHF:N-((2R,4S)-2-BUTYL-4-(3-(2-FLUOROPHENYL)UREIDO)-5-METHYL-3-OXOHEXYL)-N-HYDROXYFORMAMIDE'>FHF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u7k|3u7k]], [[3u7l|3u7l]], [[3u7n|3u7n]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sacol1100 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7m OCA], [https://pdbe.org/3u7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7m RCSB], [https://www.ebi.ac.uk/pdbsum/3u7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7m OCA], [https://pdbe.org/3u7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u7m RCSB], [https://www.ebi.ac.uk/pdbsum/3u7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
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[https://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peptide deformylase]]
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[[Category: Staphylococcus aureus subsp. aureus COL]]
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[[Category: Staac]]
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[[Category: Kim KK]]
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[[Category: Kim, K K]]
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[[Category: Lee BJ]]
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[[Category: Lee, B J]]
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[[Category: Lee HH]]
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[[Category: Lee, H H]]
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[[Category: Lee S-J]]
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[[Category: Lee, S J]]
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[[Category: Lee SJ]]
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[[Category: Lee, S K]]
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[[Category: Lee SK]]
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[[Category: Suh, S W]]
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[[Category: Suh SW]]
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[[Category: Yoon, H J]]
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[[Category: Yoon H-J]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Pdf]]
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[[Category: Pdf-inhibitor]]
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Current revision

Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors

PDB ID 3u7m

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