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8e05
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of dimeric LRRK1== | |
| + | <StructureSection load='8e05' size='340' side='right'caption='[[8e05]], [[Resolution|resolution]] 4.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8e05]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E05 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e05 OCA], [https://pdbe.org/8e05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e05 RCSB], [https://www.ebi.ac.uk/pdbsum/8e05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e05 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/LRRK1_HUMAN LRRK1_HUMAN] Osteosclerotic metaphyseal dysplasia. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LRRK1_HUMAN LRRK1_HUMAN] Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.[UniProtKB:Q3UHC2] | ||
| - | + | ==See Also== | |
| - | + | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Leschziner AE]] | ||
| + | [[Category: Lin YX]] | ||
| + | [[Category: Reimer JM]] | ||
Current revision
Structure of dimeric LRRK1
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