5m2c

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(New page: '''Unreleased structure''' The entry 5m2c is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (18:21, 1 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5m2c is ON HOLD
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==Structural tuning of CD81LEL (space group P32 1 2)==
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<StructureSection load='5m2c' size='340' side='right'caption='[[5m2c]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5m2c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M2C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.961&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m2c OCA], [https://pdbe.org/5m2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m2c RCSB], [https://www.ebi.ac.uk/pdbsum/5m2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m2c ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[https://omim.org/entry/613496 613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hepatitis C virus (HCV) enters into human hepatocytes via tetraspanin hCD81. HCV glycoprotein E2 recognizes the "head" subdomain of the large extracellular loop (LEL) of CD81 (hCD81LEL), but the precise mechanism of virus cell attachment and entry remains elusive. Here, by combining the structural analysis of a conspicuous number of crystallized CD81LEL molecules with molecular dynamics simulations, we show that the conformational plasticity of the hCD81LEL head subdomain is a molecular property of the receptor. The observed closed, intermediate, and open conformations of the head subdomain provide distinct binding platforms. Simulations at pH 7.4 and 4.0 indicate that this dynamism is pH modulated. The crystallized double conformation of the disulfide bridge C157-C175 at the base of the head subdomain identifies this bond as the molecular zipper of the plasticity of hCD81LEL. We propose that this conformational dependence of hCD81LEL, which is finely tuned by pH and redox conditions, enables the virus-receptor interactions to diversely re-engage at endosomal conditions.
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Authors:
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Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop.,Cunha ES, Sfriso P, Rojas AL, Hospital A, Orozco M, Abrescia NG Structure. 2016 Nov 21. pii: S0969-2126(16)30343-4. doi:, 10.1016/j.str.2016.11.003. PMID:27916518<ref>PMID:27916518</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5m2c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CD81|CD81]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Abrescia NG]]
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[[Category: Cunha ES]]
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[[Category: Hospital A]]
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[[Category: Orozco M]]
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[[Category: Rojas AL]]
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[[Category: Roversi P]]
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[[Category: Sfriso P]]

Current revision

Structural tuning of CD81LEL (space group P32 1 2)

PDB ID 5m2c

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