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5m4r

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==Structural tuning of CD81LEL (space group C2)==
==Structural tuning of CD81LEL (space group C2)==
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<StructureSection load='5m4r' size='340' side='right' caption='[[5m4r]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='5m4r' size='340' side='right'caption='[[5m4r]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5m4r]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M4R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5m4r]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M4R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5m2c|5m2c]], [[5m3d|5m3d]], [[5m33|5m33]], [[5m3t|5m3t]], [[1g8q|1g8q]], [[1iv5|1iv5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4r OCA], [http://pdbe.org/5m4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m4r RCSB], [http://www.ebi.ac.uk/pdbsum/5m4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m4r OCA], [https://pdbe.org/5m4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m4r RCSB], [https://www.ebi.ac.uk/pdbsum/5m4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m4r ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
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[https://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[https://omim.org/entry/613496 613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
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[https://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5m4r" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5m4r" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CD81|CD81]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abrescia, N G.A]]
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[[Category: Homo sapiens]]
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[[Category: Cell adhesion]]
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[[Category: Large Structures]]
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[[Category: Human cellular receptor for hepatitis c virus]]
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[[Category: Abrescia NG]]
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[[Category: Cunha ES]]
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[[Category: Hospital A]]
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[[Category: Orozco M]]
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[[Category: Rojas AL]]
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[[Category: Roversi P]]
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[[Category: Sfriso P]]

Current revision

Structural tuning of CD81LEL (space group C2)

PDB ID 5m4r

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