This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5m50

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:26, 1 November 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins==
==Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins==
-
<StructureSection load='5m50' size='340' side='right' caption='[[5m50]], [[Resolution|resolution]] 5.30&Aring;' scene=''>
+
<SX load='5m50' size='340' side='right' viewer='molstar' caption='[[5m50]], [[Resolution|resolution]] 5.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5m50]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M50 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5m50]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M50 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.3&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Camsap3, Kiaa1543 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m50 OCA], [http://pdbe.org/5m50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m50 RCSB], [http://www.ebi.ac.uk/pdbsum/5m50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m50 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m50 OCA], [https://pdbe.org/5m50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m50 RCSB], [https://www.ebi.ac.uk/pdbsum/5m50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m50 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/F2Z4C1_BOVIN F2Z4C1_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00824325] [[http://www.uniprot.org/uniprot/CAMP3_MOUSE CAMP3_MOUSE]] Microtubule minus-end binding protein that acts as a regulator of microtubule dynamics. Specifically required for zonula adherens biogenesis and maintenance by anchoring microtubules at their minus-ends to zonula adherens, leading to recruit KIFC3 kinesin to junctional site (By similarity). [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
+
[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 22:
<references/>
<references/>
__TOC__
__TOC__
-
</StructureSection>
+
</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Lk3 transgenic mice]]
+
[[Category: Large Structures]]
-
[[Category: Akhmanova, A]]
+
[[Category: Mus musculus]]
-
[[Category: Atherton, J]]
+
[[Category: Akhmanova A]]
-
[[Category: Baldus, M]]
+
[[Category: Atherton J]]
-
[[Category: Grant, B J]]
+
[[Category: Baldus M]]
-
[[Category: Hooff, J J.E van]]
+
[[Category: Grant BJ]]
-
[[Category: Houben, K]]
+
[[Category: Houben K]]
-
[[Category: Hua, S]]
+
[[Category: Hua S]]
-
[[Category: Jiang, K]]
+
[[Category: Jiang K]]
-
[[Category: Joseph, A P]]
+
[[Category: Joseph A-P]]
-
[[Category: Luo, Y]]
+
[[Category: Luo Y]]
-
[[Category: Moores, C A]]
+
[[Category: Moores CA]]
-
[[Category: Roberts, A J]]
+
[[Category: Roberts AJ]]
-
[[Category: Scarabelli, G]]
+
[[Category: Scarabelli G]]
-
[[Category: Stangier, M M]]
+
[[Category: Stangier MM]]
-
[[Category: Steinmetz, M O]]
+
[[Category: Steinmetz MO]]
-
[[Category: Topf, M]]
+
[[Category: Topf M]]
-
[[Category: Camsap ckk microtubule tubulin]]
+
[[Category: Van Hooff JJE]]
-
[[Category: Structural protein]]
+

Current revision

Mechanism of microtubule minus-end recognition and protection by CAMSAP proteins

5m50, resolution 5.30Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5m50"
Personal tools