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5m8q

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Current revision (18:30, 1 November 2023) (edit) (undo)
 
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<StructureSection load='5m8q' size='340' side='right'caption='[[5m8q]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
<StructureSection load='5m8q' size='340' side='right'caption='[[5m8q]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5m8q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M8Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5m8q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M8Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=KOJ:5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE'>KOJ</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TYRP1, CAS2, TYRP, TYRRP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=KOJ:5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE'>KOJ</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8q OCA], [http://pdbe.org/5m8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m8q RCSB], [http://www.ebi.ac.uk/pdbsum/5m8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m8q OCA], [https://pdbe.org/5m8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m8q RCSB], [https://www.ebi.ac.uk/pdbsum/5m8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m8q ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN]] Oculocutaneous albinism type 3. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN] Oculocutaneous albinism type 3. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN]] Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.[UniProtKB:P07147]
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[https://www.uniprot.org/uniprot/TYRP1_HUMAN TYRP1_HUMAN] Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.[UniProtKB:P07147]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dijkstra, B W]]
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[[Category: Dijkstra BW]]
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[[Category: Lai, X]]
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[[Category: Lai X]]
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[[Category: Soler-Lopez, M]]
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[[Category: Soler-Lopez M]]
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[[Category: Wichers, H J]]
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[[Category: Wichers HJ]]
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[[Category: Human tyrosinase related protein 1]]
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[[Category: Melanin biosynthesis]]
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[[Category: Oxidoreductase]]
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[[Category: Tyrosinase]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with kojic acid

PDB ID 5m8q

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