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RNA ligase

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{{STRUCTURE_1vgj| PDB=1vgj | SIZE=300| SCENE=RNA_ligase/Cv/1 |right|CAPTION=Se-Met RNA ligase [[1vgj]] }}
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<StructureSection load='' size='350' side='right' scene='RNA_ligase/Cv/1' caption='Se-Met RNA ligase (PDB code [[1vgj]])'>
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'''RNA ligase''' (LigR) is an enzyme which ligates two ribonucleotide chains using ATP and producing AMP, diphosphate and the ligated ribonucleotide chain<ref>PMID:18972386</ref>. '''RNA ligase RtcB''' joins 2',3'-cyclic phosphate and 5'-OH ends<ref>PMID:21757685</ref>. See more details in [[T4 RNA ligase 2 (Rnl2)]] and [[Ligases]].
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'''RNA ligase''' (LigR) is an enzyme which ligates two ribonucleotide chains using ATP and producing AMP, diphosphate and the ligated ribonucleotide chain<ref>PMID:18972386</ref>. See more details in [[T4 RNA ligase 2 (Rnl2)]] and [[Ligases]].
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</StructureSection>
== 3D Structures of RNA ligase ==
== 3D Structures of RNA ligase ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* RNA ligase
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**[[2c5u]] – T4LigR 1 RNA-binding domain - Enterobacteria phage T4<br />
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**[[1s68]] - T4LigR 2 N-terminal<br />
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**[[1vgj]], [[1vdx]] – PhLigR – ''Pyrococcus horikoshii''<br />
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**[[8dcg]] – PhLigR RtcB <br />
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**[[2vug]] – LigR – ''Pyrococcus abyssi''<br />
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**[[1xdn]] – LigR 1 editing – ''Trypanosoma brucei''<br />
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**[[1iuh]] – LigR 2’-5’ – ''Thermus thermophilus''<br />
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**[[5cot]] – aLigR – amoeba<br />
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**[[6vt0]], [[6vt1]], [[6vt3]], [[6vt4]], [[6vt5]], [[6vtg]], [[5cov]] – aLigR (mutant) <br />
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* RNA ligase complex
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**[[7p3b]] – hLigR RtcB + GMP + Co - human<br />
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**[[5tt6]] – T4LigR 1 + ATP<br />
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**[[2hvr]], [[2hvs]] – T4LigR 2 + DNA + nucleotide <br />
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**[[2hvq]] - T4LigR 2 + adenosine derivative<br />
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**[[4qak]] - LigR 2’-5’ + AMP – ''Escherichia coli''<br />
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**[[5cou]], [[6vt6]], [[6vt8]], [[6vt9]], [[6vtb]], [[6vtd]] – aLigR (mutant) + ATP<br />
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**[[6vte]] – aLigR (mutant) + AMP<br />
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**[[6vtf]] – aLigR + pyrophosphate<br />
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**[[5d1o]], [[5d1p]] – LigR ATP-dependent + ATP – ''Methanothermobacter thermautotrophicus''<br />
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**[[4isz]], [[8dc9]], [[8dca]], [[8dcb]], [[8dcd]], [[8dcf]] – PhLigR RtcB + GTP + ion<br />
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**[[4dwq]], [[4it0]] – PhLigR RtcB + GMP + Mn<br />
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**[[4isj]], [[4dwr]] – PhLigR RtcB + Mn<br />
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**[[7lfq]] – PhLigR RtcB + DNA<br />
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[[2hvr]], [[2hvs]] – T4LigR 2 + DNA + nucleotide – Enterobacteria phage T4<br />
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}}
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[[1s68]] - T4LigR 2 N-terminal<br />
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[[2c5u]] – T4LigR 1 RNA-binding domain<br />
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[[1vgj]], [[1vdx]] – LigR – ''Pyrococcus horikoshii''<br />
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[[2vug]] – LigR – ''Pyrococcus abyssi''<br />
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[[1xdn]] – LigR 1 editing – ''Trypanosoma brucei''<br />
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[[1iuh]] – LigR 2’-5’ – ''Thermus thermophilus''<br />
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[[4qak]] - LigR 2’-5’ – ''Escherichia coli''<br />
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== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Se-Met RNA ligase (PDB code 1vgj)

Drag the structure with the mouse to rotate

3D Structures of RNA ligase

Updated on 05-November-2023

References

  1. ↑ Nichols NM, Tabor S, McReynolds LA. RNA ligases. Curr Protoc Mol Biol. 2008 Oct;Chapter 3:Unit3.15. doi:, 10.1002/0471142727.mb0315s84. PMID:18972386 doi:http://dx.doi.org/10.1002/0471142727.mb0315s84
  2. ↑ Tanaka N, Meineke B, Shuman S. RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. J Biol Chem. 2011 Sep 2;286(35):30253-30257. PMID:21757685 doi:10.1074/jbc.C111.274597

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