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8qlr
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8qlr is ON HOLD Authors: Balourdas, D.I., Rak, M., Knapp, S., Joerger, A.C. Description: Human MST3 (STK24) kinase in complex with inhibitor MR24 [...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human MST3 (STK24) kinase in complex with inhibitor MR24== | |
| - | + | <StructureSection load='8qlr' size='340' side='right'caption='[[8qlr]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8qlr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QLR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=VYN:8-(4-azanylbutyl)-2-[1,3-bis(oxidanyl)propan-2-ylamino]-6-[2-chloranyl-4-(6-methylpyridin-2-yl)phenyl]pyrido[2,3-d]pyrimidin-7-one'>VYN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qlr OCA], [https://pdbe.org/8qlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qlr RCSB], [https://www.ebi.ac.uk/pdbsum/8qlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qlr ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Knapp | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Balourdas DI]] | ||
| + | [[Category: Joerger AC]] | ||
| + | [[Category: Knapp S]] | ||
| + | [[Category: Rak M]] | ||
Current revision
Human MST3 (STK24) kinase in complex with inhibitor MR24
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