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3vka

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==Crystal structure of MoeO5 soaked for 3 hours in FsPP==
==Crystal structure of MoeO5 soaked for 3 hours in FsPP==
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<StructureSection load='3vka' size='340' side='right' caption='[[3vka]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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<StructureSection load='3vka' size='340' side='right'caption='[[3vka]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vka]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_ghanaensis Streptomyces ghanaensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VKA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vka]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_viridosporus_ATCC_14672 Streptomyces viridosporus ATCC 14672]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VKA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPQ:(2R)-3-(PHOSPHONOOXY)-2-{[(2Z,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIEN-1-YL]OXY}PROPANOIC+ACID'>FPQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vk5|3vk5]], [[3vkb|3vkb]], [[3vkc|3vkc]], [[3vkd|3vkd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPQ:(2R)-3-(PHOSPHONOOXY)-2-{[(2Z,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIEN-1-YL]OXY}PROPANOIC+ACID'>FPQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">moeO5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=35758 Streptomyces ghanaensis])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vka OCA], [https://pdbe.org/3vka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vka RCSB], [https://www.ebi.ac.uk/pdbsum/3vka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vka ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vka OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vka RCSB], [http://www.ebi.ac.uk/pdbsum/3vka PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A011_STRVD A0A011_STRVD]
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New antibiotics are needed because of the increasing occurrence of multidrug resistance, as seen in Staphylococcus aureus (MRSA). The initiating step of the biosynthesis of the next-generation drug moenomycin is catalyzed by MoeO5, which is a prenyltransferase with triose-phosphate-isomerase barrel structure as was shown by E. Oldfield, R.-T. Guo, and co-workers in their Communication (DOI:10.1002/anie.201108002). The transferred farnesyl group undergoes a trans-to-cis conversion in its first double bond.
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Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes.,Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, Wang AH, Oldfield E, Guo RT Angew Chem Int Ed Engl. 2012 Mar 20. doi: 10.1002/anie.201201339. PMID:22434765<ref>PMID:22434765</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptomyces ghanaensis]]
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[[Category: Large Structures]]
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[[Category: Guo, R T]]
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[[Category: Streptomyces viridosporus ATCC 14672]]
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[[Category: Huang, C H]]
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[[Category: Guo R-T]]
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[[Category: Ko, T P]]
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[[Category: Huang C-H]]
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[[Category: Ren, F]]
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[[Category: Ko T-P]]
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[[Category: Tim barrel]]
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[[Category: Ren F]]
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[[Category: Transferase]]
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Current revision

Crystal structure of MoeO5 soaked for 3 hours in FsPP

PDB ID 3vka

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