3vqf

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{{STRUCTURE_3vqf| PDB=3vqf | SCENE= }}
 
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===Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein===
 
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==About this Structure==
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==Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein==
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[[3vqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA].
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<StructureSection load='3vqf' size='340' side='right'caption='[[3vqf]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vqf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VQF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.199&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vqf OCA], [https://pdbe.org/3vqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vqf RCSB], [https://www.ebi.ac.uk/pdbsum/3vqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vqf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LNX1_MOUSE LNX1_MOUSE] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Akiyoshi, Y.]]
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[[Category: Akiyoshi Y]]
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[[Category: Furuse, M.]]
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[[Category: Furuse M]]
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[[Category: Goda, N.]]
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[[Category: Goda N]]
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[[Category: Hamada, D.]]
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[[Category: Hamada D]]
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[[Category: Hiroaki, H.]]
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[[Category: Hiroaki H]]
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[[Category: Nakagawa, A.]]
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[[Category: Nakagawa A]]
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[[Category: Narita, H.]]
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[[Category: Narita H]]
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[[Category: Suzuki, M.]]
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[[Category: Suzuki M]]
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[[Category: Tenno, T.]]
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[[Category: Tenno T]]
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[[Category: Claudin c-terminus]]
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[[Category: Pdz domain]]
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[[Category: Peptide binding protein]]
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Current revision

Crystal Structure Analysis of the PDZ Domain Derived from the Tight Junction Regulating Protein

PDB ID 3vqf

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