3vts
From Proteopedia
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| - | [[Image:3vts.jpg|left|200px]] | ||
| - | + | ==Crystal structure of a three finger toxin from snake venom== | |
| + | <StructureSection load='3vts' size='340' side='right'caption='[[3vts]], [[Resolution|resolution]] 2.43Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3vts]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hemachatus_haemachatus Hemachatus haemachatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VTS FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.426Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vts OCA], [https://pdbe.org/3vts PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vts RCSB], [https://www.ebi.ac.uk/pdbsum/3vts PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vts ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/3SBH_HEMHA 3SBH_HEMHA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Snake venoms are rich sources of biologically active proteins and polypeptides. Three-finger toxins are non-enzymatic proteins present in elapid (cobras, kraits, mambas and sea snakes) and colubrid venoms. These proteins contain four conserved disulfide bonds in the core to maintain the three-finger folds. Although all three-finger toxins have similar fold, their biological activities are different. A new three-finger toxin (hemachatoxin) was isolated from Hemachatus haemachatus (Ringhals cobra) venom. Its amino acid sequence was elucidated, and crystal structure was determined at 2.43 A resolution. The overall fold is similar to other three-finger toxins. The structure and sequence analysis revealed that the fold is maintained by four highly conserved disulfide bonds. It exhibited highest similarity to particularly P-type cardiotoxins that are known to associate and perturb the membrane surface with their lipid binding sites. Also, the increased B value of hemachotoxin loop II suggests that loop II is flexible and may remain flexible until its interaction with membrane phospholipids. Based on the analysis, we predict hemachatoxin to be cardiotoxic/cytotoxic and our future experiments will be directed to characterize the activity of hemachatoxin. | ||
| - | + | Identification and structural characterization of a new three-finger toxin hemachatoxin from Hemachatus haemachatus venom.,Girish VM, Kumar S, Joseph L, Jobichen C, Kini RM, Sivaraman J PLoS One. 2012;7(10):e48112. doi: 10.1371/journal.pone.0048112. Epub 2012 Oct 29. PMID:23144733<ref>PMID:23144733</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | == | + | </div> |
| - | + | <div class="pdbe-citations 3vts" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hemachatus haemachatus]] | [[Category: Hemachatus haemachatus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Jobichen C]] |
| - | [[Category: | + | [[Category: Sivaraman J]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of a three finger toxin from snake venom
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