This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3vxd
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of unsaturated glucuronyl hydrolase mutant D115N from Streptcoccus agalactiae== | ==Crystal structure of unsaturated glucuronyl hydrolase mutant D115N from Streptcoccus agalactiae== | ||
| - | <StructureSection load='3vxd' size='340' side='right' caption='[[3vxd]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='3vxd' size='340' side='right'caption='[[3vxd]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3vxd]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3vxd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae_NEM316 Streptococcus agalactiae NEM316]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VXD FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vxd OCA], [https://pdbe.org/3vxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vxd RCSB], [https://www.ebi.ac.uk/pdbsum/3vxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vxd ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/UCDH_STRA3 UCDH_STRA3] Catalyzes the hydrolysis of unsaturated hyaluronate and chondroitin disaccharides. Also degrades unsaturated heparin disaccharides. Releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. Prefers sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans. Probably required for mammalian cells invasion through the degradation of extracellular sulfated glycosaminoglycans such as chondroitin and hyaluronan.<ref>PMID:19416976</ref> <ref>PMID:21147778</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Streptococcus agalactiae]] | + | [[Category: Large Structures]] |
| - | [[Category: Hashimoto | + | [[Category: Streptococcus agalactiae NEM316]] |
| - | [[Category: Maruyama | + | [[Category: Hashimoto W]] |
| - | [[Category: Mikami | + | [[Category: Maruyama Y]] |
| - | [[Category: Murata | + | [[Category: Mikami B]] |
| - | [[Category: Nakamichi | + | [[Category: Murata K]] |
| - | + | [[Category: Nakamichi Y]] | |
| - | + | ||
Current revision
Crystal structure of unsaturated glucuronyl hydrolase mutant D115N from Streptcoccus agalactiae
| |||||||||||
