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3vza

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==Crystal structure of the chicken Spc24-Spc25 globular domain in complex with CENP-T peptide==
==Crystal structure of the chicken Spc24-Spc25 globular domain in complex with CENP-T peptide==
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<StructureSection load='3vza' size='340' side='right' caption='[[3vza]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3vza' size='340' side='right'caption='[[3vza]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vza]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VZA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vza]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VZA FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vz9|3vz9]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.898&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPC25 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]), CENPT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vza OCA], [https://pdbe.org/3vza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vza RCSB], [https://www.ebi.ac.uk/pdbsum/3vza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vza ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vza RCSB], [http://www.ebi.ac.uk/pdbsum/3vza PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CENPT_CHICK CENPT_CHICK]] Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.<ref>PMID:19070575</ref> <ref>PMID:22304917</ref>
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[https://www.uniprot.org/uniprot/E1C4Y2_CHICK E1C4Y2_CHICK]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3vza" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Centromere protein|Centromere protein]]
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Fukagawa, T]]
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[[Category: Large Structures]]
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[[Category: Nishino, T]]
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[[Category: Fukagawa T]]
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[[Category: Cell cycle]]
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[[Category: Nishino T]]
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[[Category: Chromosome segregation]]
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[[Category: Kinetochore component]]
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[[Category: Ndc80 complex]]
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[[Category: Rwd domain]]
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Current revision

Crystal structure of the chicken Spc24-Spc25 globular domain in complex with CENP-T peptide

PDB ID 3vza

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