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3vzz

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==Crystal structure of PcrB complexed with FsPP from bacillus subtilis subap. subtilis str. 168==
==Crystal structure of PcrB complexed with FsPP from bacillus subtilis subap. subtilis str. 168==
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<StructureSection load='3vzz' size='340' side='right' caption='[[3vzz]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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<StructureSection load='3vzz' size='340' side='right'caption='[[3vzz]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vzz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VZZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vzz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VZZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vzx|3vzx]], [[3vzy|3vzy]], [[3w00|3w00]], [[3w01|3w01]], [[3w02|3w02]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pcrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 Bacillus subtilis subsp. subtilis str. 168])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vzz OCA], [https://pdbe.org/3vzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vzz RCSB], [https://www.ebi.ac.uk/pdbsum/3vzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vzz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vzz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vzz RCSB], [http://www.ebi.ac.uk/pdbsum/3vzz PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PCRB_BACSU PCRB_BACSU]] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Can not use glycerol-3-phosphate (G3P) or 3-phosphoglycerate (3PG) as an acceptor.<ref>PMID:18558723</ref> <ref>PMID:21761520</ref> <ref>PMID:21214173</ref>
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[https://www.uniprot.org/uniprot/PCRB_BACSU PCRB_BACSU] Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. To a much lesser extent, is also able to use geranyl diphosphate (GPP; C10) and geranylgeranyl diphosphate (GGPP; C20) as the prenyl donors, but not farnesyl pyrophosphate (FPP; C15). Can not use glycerol-3-phosphate (G3P) or 3-phosphoglycerate (3PG) as an acceptor.<ref>PMID:18558723</ref> <ref>PMID:21761520</ref> <ref>PMID:21214173</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3vzz" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
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[[Category: Chan, H C]]
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[[Category: Large Structures]]
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[[Category: Chen, C C]]
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[[Category: Chan HC]]
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[[Category: Feng, X]]
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[[Category: Chen CC]]
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[[Category: Guo, R T]]
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[[Category: Feng X]]
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[[Category: He, M]]
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[[Category: Guo RT]]
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[[Category: Hu, Y]]
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[[Category: He M]]
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[[Category: Huang, C H]]
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[[Category: Hu Y]]
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[[Category: Ko, T P]]
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[[Category: Huang CH]]
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[[Category: Li, Y]]
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[[Category: Ko TP]]
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[[Category: Liu, Y L]]
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[[Category: Li Y]]
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[[Category: Oldfield, E]]
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[[Category: Liu YL]]
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[[Category: Pang, X]]
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[[Category: Oldfield E]]
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[[Category: Ren, F]]
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[[Category: Pang X]]
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[[Category: Wang, K]]
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[[Category: Ren F]]
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[[Category: Biosynthesis]]
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[[Category: Wang K]]
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[[Category: Enzyme catalysis]]
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[[Category: Prenyltransferase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of PcrB complexed with FsPP from bacillus subtilis subap. subtilis str. 168

PDB ID 3vzz

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