3w2x

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==Crystal structure of DNA uridine endonuclease Mth212==
==Crystal structure of DNA uridine endonuclease Mth212==
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<StructureSection load='3w2x' size='340' side='right' caption='[[3w2x]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='3w2x' size='340' side='right'caption='[[3w2x]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3w2x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Metth Metth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W2X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3w2x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus_str._Delta_H Methanothermobacter thermautotrophicus str. Delta H]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W2X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3w2y|3w2y]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTH212, MTH_212 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=187420 METTH])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2x OCA], [https://pdbe.org/3w2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w2x RCSB], [https://www.ebi.ac.uk/pdbsum/3w2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w2x ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exodeoxyribonuclease_III Exodeoxyribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.11.2 3.1.11.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2x OCA], [http://pdbe.org/3w2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3w2x RCSB], [http://www.ebi.ac.uk/pdbsum/3w2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3w2x ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UREND_METTH UREND_METTH] Involved in DNA uracil repair (PubMed:17012282, PubMed:19240141, PubMed:20129830). Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide (PubMed:17012282, PubMed:19240141, PubMed:20129830). In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease (PubMed:15725624, PubMed:17012282). Strongly binds to double-stranded DNA (PubMed:15725624).<ref>PMID:15725624</ref> <ref>PMID:17012282</ref> <ref>PMID:19240141</ref> <ref>PMID:20129830</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Exodeoxyribonuclease III]]
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[[Category: Large Structures]]
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[[Category: Metth]]
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[[Category: Methanothermobacter thermautotrophicus str. Delta H]]
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[[Category: Arai, R]]
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[[Category: Arai R]]
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[[Category: Shida, T]]
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[[Category: Shida T]]
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[[Category: Tabata, N]]
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[[Category: Tabata N]]
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[[Category: Alpha/beta-sandwich]]
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[[Category: Dna binding]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of DNA uridine endonuclease Mth212

PDB ID 3w2x

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