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3wg4

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<StructureSection load='3wg4' size='340' side='right'caption='[[3wg4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='3wg4' size='340' side='right'caption='[[3wg4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wg4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrcy Agrcy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WG4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrocybe_cylindracea Agrocybe cylindracea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WG4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wg1|3wg1]], [[3wg2|3wg2]], [[3wg3|3wg3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PRD_900132:Blood+group+A+H+type+2+antigen,+beta+anomer'>PRD_900132</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg4 OCA], [http://pdbe.org/3wg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wg4 RCSB], [http://www.ebi.ac.uk/pdbsum/3wg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wg4 OCA], [https://pdbe.org/3wg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wg4 RCSB], [https://www.ebi.ac.uk/pdbsum/3wg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wg4 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATLE_CYCAE ATLE_CYCAE] Anti-tumor lectin with DNase activity. Inhibits the growth of several tumor cell lines in vitro. Induces lymphocyte infiltration and necrosis of tumor cells in a mouse tumor model. Induces apoptosis in HeLa cells. Binds N-acetylneuraminyl lactose (N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose) (PubMed:16051274).<ref>PMID:12757412</ref> <ref>PMID:16051274</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3wg4" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3wg4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Galectin 3D structures|Galectin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Agrcy]]
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[[Category: Agrocybe cylindracea]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hirabayashi, J]]
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[[Category: Hirabayashi J]]
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[[Category: Hu, D]]
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[[Category: Hu D]]
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[[Category: Kato, R]]
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[[Category: Kato R]]
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[[Category: Kuwabara, N]]
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[[Category: Kuwabara N]]
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[[Category: Makio, H]]
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[[Category: Makio H]]
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[[Category: Tateno, H]]
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[[Category: Tateno H]]
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[[Category: Galactose binding]]
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[[Category: Galectin]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal structure of Agrocybe cylindracea galectin mutant (N46A) with blood type A antigen tetraose

PDB ID 3wg4

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OCA

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