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3wsb
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3wsb is ON HOLD Authors: Shang, N., Li, Q., Guo, R.T., Huang, C.H., Oldfield, E. Description: The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruz...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole== |
| + | <StructureSection load='3wsb' size='340' side='right'caption='[[3wsb]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3wsb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WSB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wsb OCA], [https://pdbe.org/3wsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wsb RCSB], [https://www.ebi.ac.uk/pdbsum/3wsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wsb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q4CWB4_TRYCC Q4CWB4_TRYCC] | ||
| - | + | ==See Also== | |
| - | + | *[[Squalene synthase|Squalene synthase]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Trypanosoma cruzi strain CL Brener]] | ||
| + | [[Category: Guo RT]] | ||
| + | [[Category: Huang CH]] | ||
| + | [[Category: Li Q]] | ||
| + | [[Category: Oldfield E]] | ||
| + | [[Category: Shang N]] | ||
Current revision
The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
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