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3wv0

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==O-glycan attached to herpes simplex virus type 1 glycoprotein gB is recognized by the Ig V-set domain of human paired immunoglobulin-like type 2 receptor alpha==
==O-glycan attached to herpes simplex virus type 1 glycoprotein gB is recognized by the Ig V-set domain of human paired immunoglobulin-like type 2 receptor alpha==
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<StructureSection load='3wv0' size='340' side='right' caption='[[3wv0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3wv0' size='340' side='right'caption='[[3wv0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wv0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WV0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wv0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_KOS Human alphaherpesvirus 1 strain KOS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WV0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wuz|3wuz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wv0 OCA], [https://pdbe.org/3wv0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wv0 RCSB], [https://www.ebi.ac.uk/pdbsum/3wv0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wv0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wv0 OCA], [http://pdbe.org/3wv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wv0 RCSB], [http://www.ebi.ac.uk/pdbsum/3wv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wv0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GB_HHV1K GB_HHV1K]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress. Also plays a role, together with gK, in virus-induced cell-to-cell fusion (syncytia formation).<ref>PMID:17299053</ref>
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[https://www.uniprot.org/uniprot/PILRA_HUMAN PILRA_HUMAN] Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.<ref>PMID:10903717</ref> <ref>PMID:18358807</ref> <ref>PMID:21241660</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arase, H]]
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[[Category: Homo sapiens]]
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[[Category: Kajikawa, M]]
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[[Category: Human alphaherpesvirus 1 strain KOS]]
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[[Category: Kogure, A]]
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[[Category: Large Structures]]
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[[Category: Kuroki, K]]
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[[Category: Arase H]]
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[[Category: Maenaka, K]]
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[[Category: Kajikawa M]]
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[[Category: Maita, N]]
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[[Category: Kogure A]]
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[[Category: Nakamura, S]]
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[[Category: Kuroki K]]
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[[Category: Ose, T]]
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[[Category: Maenaka K]]
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[[Category: Satoh, T]]
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[[Category: Maita N]]
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[[Category: Tabata, S]]
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[[Category: Nakamura S]]
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[[Category: Wang, J]]
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[[Category: Ose T]]
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[[Category: Yamaguchi, M]]
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[[Category: Satoh T]]
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[[Category: Immunoglobulin-like]]
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[[Category: Tabata S]]
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[[Category: Immunological receptor]]
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[[Category: Wang J]]
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[[Category: Membrane]]
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[[Category: Yamaguchi M]]
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[[Category: Membrane protein]]
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Current revision

O-glycan attached to herpes simplex virus type 1 glycoprotein gB is recognized by the Ig V-set domain of human paired immunoglobulin-like type 2 receptor alpha

PDB ID 3wv0

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