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4e12
From Proteopedia
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| - | [[Image:4e12.jpg|left|200px]] | ||
| - | + | ==Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase== | |
| + | <StructureSection load='4e12' size='340' side='right'caption='[[4e12]], [[Resolution|resolution]] 1.93Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4e12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baylyi Acinetobacter baylyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E12 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e12 OCA], [https://pdbe.org/4e12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e12 RCSB], [https://www.ebi.ac.uk/pdbsum/4e12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e12 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B1P3E1_ACIBI B1P3E1_ACIBI] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product. | ||
| - | + | Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase.,Lu M, Huang Y, White MA, Wu X, Liu N, Cheng X, Chen Y Chem Commun (Camb). 2012 Oct 24;48(92):11352-4. doi: 10.1039/c2cc36334h. PMID:23073461<ref>PMID:23073461</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | == | + | </div> |
| - | + | <div class="pdbe-citations 4e12" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Acinetobacter baylyi]] | [[Category: Acinetobacter baylyi]] | ||
| - | [[Category: Chen | + | [[Category: Large Structures]] |
| - | [[Category: Cheng | + | [[Category: Chen Y]] |
| - | [[Category: Huang | + | [[Category: Cheng X]] |
| - | [[Category: Liu | + | [[Category: Huang Y]] |
| - | [[Category: Lu | + | [[Category: Liu N]] |
| - | [[Category: White | + | [[Category: Lu M]] |
| - | [[Category: Wu | + | [[Category: White MA]] |
| - | + | [[Category: Wu X]] | |
| - | + | ||
Current revision
Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase
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Categories: Acinetobacter baylyi | Large Structures | Chen Y | Cheng X | Huang Y | Liu N | Lu M | White MA | Wu X
