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4es5

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==Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Bar-headed Gs/Qinghai/15c/2005 (h5n1) with bound m7GTP==
==Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Bar-headed Gs/Qinghai/15c/2005 (h5n1) with bound m7GTP==
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<StructureSection load='4es5' size='340' side='right' caption='[[4es5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4es5' size='340' side='right'caption='[[4es5]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4es5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/bar-headed_goose/qinghai/59/05(h5n1)) Influenza a virus (a/bar-headed goose/qinghai/59/05(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ES5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ES5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4es5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Bar-headed_Goose/Qinghai/59/05(H5N1)) Influenza A virus (A/Bar-headed Goose/Qinghai/59/05(H5N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ES5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ES5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=336232 Influenza A virus (A/Bar-headed Goose/Qinghai/59/05(H5N1))])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4es5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4es5 OCA], [http://pdbe.org/4es5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4es5 RCSB], [http://www.ebi.ac.uk/pdbsum/4es5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4es5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4es5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4es5 OCA], [https://pdbe.org/4es5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4es5 RCSB], [https://www.ebi.ac.uk/pdbsum/4es5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4es5 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4FAU9_9INFA Q4FAU9_9INFA] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds the 7-methylguanosine-containing cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with and inhibition of the host mitochondrial antiviral signaling protein MAVS.[HAMAP-Rule:MF_04062]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Liu, Y]]
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[[Category: Large Structures]]
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[[Category: Meng, G]]
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[[Category: Liu Y]]
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[[Category: Zheng, X]]
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[[Category: Meng G]]
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[[Category: Cap-binding protein]]
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[[Category: Zheng X]]
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[[Category: Transcription]]
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Current revision

Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Bar-headed Gs/Qinghai/15c/2005 (h5n1) with bound m7GTP

PDB ID 4es5

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