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4g44

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==Structure of P450 CYP121 in complex with lead compound MB286, 3-((1H-1,2,4-triazol-1-yl)methyl)aniline==
==Structure of P450 CYP121 in complex with lead compound MB286, 3-((1H-1,2,4-triazol-1-yl)methyl)aniline==
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<StructureSection load='4g44' size='340' side='right' caption='[[4g44]], [[Resolution|resolution]] 1.24&Aring;' scene=''>
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<StructureSection load='4g44' size='340' side='right'caption='[[4g44]], [[Resolution|resolution]] 1.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4g44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G44 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4g44]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G44 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TZM:3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)ANILINE'>TZM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.24&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g1x|4g1x]], [[4g2g|4g2g]], [[1n40|1n40]], [[3g5h|3g5h]], [[4g45|4g45]], [[4g46|4g46]], [[4g47|4g47]], [[4g48|4g48]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TZM:3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)ANILINE'>TZM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv2276 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g44 OCA], [https://pdbe.org/4g44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g44 RCSB], [https://www.ebi.ac.uk/pdbsum/4g44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g44 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g44 OCA], [http://pdbe.org/4g44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g44 RCSB], [http://www.ebi.ac.uk/pdbsum/4g44 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g44 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CP121_MYCTU CP121_MYCTU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Cytochrome P450|Cytochrome P450]]
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abell, C]]
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[[Category: Large Structures]]
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[[Category: Ciulli, A]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Hudson, S A]]
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[[Category: Abell C]]
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[[Category: Leys, D]]
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[[Category: Ciulli A]]
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[[Category: McLean, K J]]
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[[Category: Hudson SA]]
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[[Category: Munro, A W]]
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[[Category: Leys D]]
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[[Category: Surade, S]]
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[[Category: McLean KJ]]
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[[Category: Yang, Y Q]]
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[[Category: Munro AW]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Surade S]]
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[[Category: P450]]
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[[Category: Yang Y-Q]]

Current revision

Structure of P450 CYP121 in complex with lead compound MB286, 3-((1H-1,2,4-triazol-1-yl)methyl)aniline

PDB ID 4g44

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