4j4q

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{{STRUCTURE_4j4q| PDB=4j4q | SCENE= }}
 
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===Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside===
 
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{{ABSTRACT_PUBMED_24038729}}
 
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==Function==
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==Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside==
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[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
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<StructureSection load='4j4q' size='340' side='right'caption='[[4j4q]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PRD_900006:trehalose'>PRD_900006</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [https://pdbe.org/4j4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [https://www.ebi.ac.uk/pdbsum/4j4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.
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==About this Structure==
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Opsin, a structural model for olfactory receptors?,Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11021-4. doi: 10.1002/anie.201302374. , Epub 2013 Aug 26. PMID:24038729<ref>PMID:24038729</ref>
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[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024038729</ref><references group="xtra"/><references/>
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</div>
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<div class="pdbe-citations 4j4q" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Rhodopsin 3D structures|Rhodopsin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Choe, H W.]]
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[[Category: Large Structures]]
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[[Category: Ernst, O P.]]
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[[Category: Choe HW]]
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[[Category: Hofmann, K P.]]
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[[Category: Ernst OP]]
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[[Category: Hong, J E.]]
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[[Category: Hofmann KP]]
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[[Category: Li, Y.]]
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[[Category: Hong JE]]
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[[Category: Morizumi, T.]]
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[[Category: Li Y]]
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[[Category: Pai, E F.]]
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[[Category: Morizumi T]]
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[[Category: Park, J H.]]
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[[Category: Pai EF]]
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[[Category: G-protein coupled receptor]]
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[[Category: Park JH]]
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[[Category: Galpha subunit]]
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[[Category: Glycoprotein]]
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[[Category: Gtp-binding]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Myristate]]
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[[Category: Nucleotide-binding]]
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[[Category: Photoreceptor protein]]
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[[Category: Receptor retinal protein]]
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[[Category: Retinal binding]]
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[[Category: Sensory transduction]]
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[[Category: Signaling protein]]
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[[Category: Transducer]]
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[[Category: Transmembrane]]
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Current revision

Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside

PDB ID 4j4q

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