4jdb

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{{STRUCTURE_4jdb| PDB=4jdb | SCENE= }}
 
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===Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-005===
 
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==Function==
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==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-005==
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[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
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<StructureSection load='4jdb' size='340' side='right'caption='[[4jdb]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jdb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JDB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JDB:5-[2-(7-METHOXYNAPHTHALEN-2-YL)ETHYL]-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>JDB</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jdb OCA], [https://pdbe.org/4jdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jdb RCSB], [https://www.ebi.ac.uk/pdbsum/4jdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jdb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
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==About this Structure==
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==See Also==
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[[4jdb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JDB OCA].
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*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
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[[Category: Aoki, T.]]
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__TOC__
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[[Category: Balogun, E O.]]
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</StructureSection>
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[[Category: Harada, S.]]
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[[Category: Large Structures]]
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[[Category: Hashimoto, S.]]
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[[Category: Trypanosoma cruzi strain CL Brener]]
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[[Category: Honma, T.]]
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[[Category: Aoki T]]
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[[Category: Iida, M.]]
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[[Category: Balogun EO]]
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[[Category: Inaoka, D K.]]
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[[Category: Harada S]]
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[[Category: Inoue, M.]]
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[[Category: Hashimoto S]]
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[[Category: Kita, K.]]
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[[Category: Honma T]]
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[[Category: Kuranaga, T.]]
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[[Category: Iida M]]
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[[Category: Lee, N.]]
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[[Category: Inaoka DK]]
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[[Category: Matsuoka, S.]]
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[[Category: Inoue M]]
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[[Category: Nara, T.]]
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[[Category: Kita K]]
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[[Category: Sakamoto, K.]]
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[[Category: Kuranaga T]]
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[[Category: Shiba, T.]]
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[[Category: Lee N]]
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[[Category: Suzuki, S.]]
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[[Category: Matsuoka S]]
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[[Category: Tabuchi, T.]]
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[[Category: Nara T]]
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[[Category: Tanaka, A.]]
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[[Category: Sakamoto K]]
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[[Category: Cytosol]]
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[[Category: Shiba T]]
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[[Category: Dihydroorotate/orotate and fumarate/succinate binding]]
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[[Category: Suzuki S]]
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[[Category: Oxidoreductase]]
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[[Category: Tabuchi T]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tanaka A]]
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[[Category: Rossmann fold]]
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Current revision

Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with MII-5-005

PDB ID 4jdb

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