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4kep

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<StructureSection load='4kep' size='340' side='right'caption='[[4kep]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
<StructureSection load='4kep' size='340' side='right'caption='[[4kep]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kep]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesorhizobium_japonicum_(strain_lmg_29417_/_cect_9101_/_maff_303099) Mesorhizobium japonicum (strain lmg 29417 / cect 9101 / maff 303099)]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3aj0 3aj0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KEP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kep]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesorhizobium_japonicum_MAFF_303099 Mesorhizobium japonicum MAFF 303099]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3aj0 3aj0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KEP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3aj3|3aj3]], [[4keq|4keq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mlr6805 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=266835 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kep OCA], [https://pdbe.org/4kep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kep RCSB], [https://www.ebi.ac.uk/pdbsum/4kep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kep ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-pyridoxolactonase 4-pyridoxolactonase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.27 3.1.1.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kep OCA], [http://pdbe.org/4kep PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kep RCSB], [http://www.ebi.ac.uk/pdbsum/4kep PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kep ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDLA_RHILO PDLA_RHILO]] Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Hydrolyzes 4-pyridoxolactone to 4-pyridoxic acid. Has lower activity toward N-hexanoyl-D,L-homoserine lactone, but is not active toward 5-pyridoxolactone and gamma-butyrolactone.
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[https://www.uniprot.org/uniprot/PDLA_RHILO PDLA_RHILO] Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Hydrolyzes 4-pyridoxolactone to 4-pyridoxic acid. Has lower activity toward N-hexanoyl-D,L-homoserine lactone, but is not active toward 5-pyridoxolactone and gamma-butyrolactone.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 4-pyridoxolactonase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baba, S]]
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[[Category: Mesorhizobium japonicum MAFF 303099]]
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[[Category: Kobayashi, J]]
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[[Category: Baba S]]
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[[Category: Mikami, B]]
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[[Category: Kobayashi J]]
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[[Category: Mizutani, K]]
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[[Category: Mikami B]]
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[[Category: Takahashi, N]]
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[[Category: Mizutani K]]
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[[Category: Yagi, T]]
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[[Category: Takahashi N]]
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[[Category: Yoshikane, Y]]
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[[Category: Yagi T]]
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[[Category: Alpha-beta/beta-alpha fold]]
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[[Category: Yoshikane Y]]
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[[Category: Hydrolase]]
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[[Category: Lactone]]
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Current revision

Crystal structure of 4-pyridoxolactonase, wild-type

PDB ID 4kep

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