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4om8

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==Crystal structure of 5-formly-3-hydroxy-2-methylpyridine 4-carboxylic acid (FHMPC) 5-dehydrogenase, an NAD+ dependent dismutase.==
==Crystal structure of 5-formly-3-hydroxy-2-methylpyridine 4-carboxylic acid (FHMPC) 5-dehydrogenase, an NAD+ dependent dismutase.==
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<StructureSection load='4om8' size='340' side='right' caption='[[4om8]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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<StructureSection load='4om8' size='340' side='right'caption='[[4om8]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4om8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OM8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4om8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesorhizobium_japonicum_MAFF_303099 Mesorhizobium japonicum MAFF 303099]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OM8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4om8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4om8 RCSB], [http://www.ebi.ac.uk/pdbsum/4om8 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4om8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4om8 OCA], [https://pdbe.org/4om8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4om8 RCSB], [https://www.ebi.ac.uk/pdbsum/4om8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4om8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FHMCD_RHILO FHMCD_RHILO] Involved in the degradation of pyridoxine (vitamin B(6)). Catalyzes the oxidation of 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate (FHMPC) by NAD(+) to 5-hydroxy-6-methylpyridine-3,4-dicarboxylate (HMPDC) (PubMed:19218190). Can also catalyze the reduction of FHMPC by NADH to 4-pyridoxic acid (PubMed:19218190).<ref>PMID:19218190</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4om8" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kobayashi, J]]
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[[Category: Large Structures]]
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[[Category: Mikami, B]]
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[[Category: Mesorhizobium japonicum MAFF 303099]]
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[[Category: Mugo, A N]]
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[[Category: Kobayashi J]]
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[[Category: Ohnishi, K]]
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[[Category: Mikami B]]
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[[Category: Yagi, T]]
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[[Category: Mugo AN]]
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[[Category: Dehydrogenase]]
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[[Category: Ohnishi K]]
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[[Category: Dismutase]]
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[[Category: Yagi T]]
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[[Category: Enzyme function initiative]]
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[[Category: Nad-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Rossmann fold]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of 5-formly-3-hydroxy-2-methylpyridine 4-carboxylic acid (FHMPC) 5-dehydrogenase, an NAD+ dependent dismutase.

PDB ID 4om8

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