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4r12

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<StructureSection load='4r12' size='340' side='right'caption='[[4r12]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4r12' size='340' side='right'caption='[[4r12]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r12]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R12 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_purpureum Dictyostelium purpureum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R12 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r12 OCA], [https://pdbe.org/4r12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r12 RCSB], [https://www.ebi.ac.uk/pdbsum/4r12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r12 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r12 OCA], [https://pdbe.org/4r12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r12 RCSB], [https://www.ebi.ac.uk/pdbsum/4r12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r12 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NICA_DICPU NICA_DICPU] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).[UniProtKB:Q92542]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dictyostelium purpureum]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lu, P]]
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[[Category: Lu P]]
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[[Category: Ma, D]]
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[[Category: Ma D]]
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[[Category: Shi, Y]]
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[[Category: Shi Y]]
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[[Category: Sun, L]]
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[[Category: Sun L]]
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[[Category: Xie, T]]
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[[Category: Xie T]]
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[[Category: Yan, C]]
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[[Category: Yan C]]
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[[Category: Yang, G]]
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[[Category: Yang G]]
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[[Category: Zhao, Y]]
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[[Category: Zhao Y]]
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[[Category: Zhou, R]]
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[[Category: Zhou R]]
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[[Category: Alpha/beta]]
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[[Category: Gamma-secretase complex]]
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[[Category: Nicastrin]]
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[[Category: Protein binding]]
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[[Category: Putative substrate-recruiting component]]
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Current revision

Crystal structure of the gamma-secretase component Nicastrin

PDB ID 4r12

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