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4ra2
From Proteopedia
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==PP2Ca== | ==PP2Ca== | ||
| - | <StructureSection load='4ra2' size='340' side='right' caption='[[4ra2]], [[Resolution|resolution]] 1.94Å' scene=''> | + | <StructureSection load='4ra2' size='340' side='right'caption='[[4ra2]], [[Resolution|resolution]] 1.94Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4ra2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RA2 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4ra2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RA2 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ra2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ra2 OCA], [https://pdbe.org/4ra2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ra2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ra2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ra2 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref> |
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| + | ==See Also== | ||
| + | *[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Liu | + | [[Category: Large Structures]] |
| - | [[Category: Meng | + | [[Category: Liu HD]] |
| - | [[Category: Pan | + | [[Category: Meng FG]] |
| - | [[Category: Sun | + | [[Category: Pan C]] |
| - | [[Category: Tang | + | [[Category: Sun JP]] |
| - | [[Category: Wang | + | [[Category: Tang JY]] |
| - | [[Category: Wang | + | [[Category: Wang HA]] |
| - | [[Category: Xiao | + | [[Category: Wang WB]] |
| - | [[Category: Xu | + | [[Category: Xiao P]] |
| - | [[Category: Yu | + | [[Category: Xu YF]] |
| - | + | [[Category: Yu X]] | |
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Current revision
PP2Ca
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Categories: Homo sapiens | Large Structures | Liu HD | Meng FG | Pan C | Sun JP | Tang JY | Wang HA | Wang WB | Xiao P | Xu YF | Yu X
